Bruker Corporation (Nasdaq: BRKR) today announced the launch of the nVista 2P miniature, two-photon microscope, a groundbreaking addition to the Inscopix product line for functional imaging of freely behaving animals. It leverages advanced two-photon fluorescence microscopy technology to enable high-resolution imaging at greater depths with 3D data reconstruction, providing researchers with unprecedented insights into neuronal activity. Featuring several innovations in miniscope design, nVista 2P offers enhanced resolution for sub-cellular imaging and mapping of neural circuit dynamics.
The nVista 2P miniscope is a self-contained, complete microscope that weighs only about 2 grams. This system offers single-cell resolution with imaging depths up to 300 microns to enable detailed exploration of densely labelled and deep regions, such as the entorhinal cortex and hypothalamus. The system is ideal for investigating disease models and key processes (e.g., spatial memory and neurotransmitter signaling). It is compatible with both shallow and deep GRIN lens applications and cranial window preparations, targeting all regions of a rodent’s brain with the same protocols used in one-photon experiments.
The 2P miniscope’s lightweight, compact, and adaptable design, paired with its thoughtfully crafted, intuitive interface, ensures exceptional ease of use,” said Mostafizur Rahman, Postdoctoral Fellow at the Dulac Lab, Harvard University. “It significantly advances our ability to address compelling scientific questions. Having previously relied on the Inscopix 1P miniscope, we have experienced a seamless transition to the 2P miniscope, further amplifying its value as a powerful tool for our research.”
“The introduction of nVista 2P marks a major step forward in free-roaming miniscope innovation that complements Bruker’s industry-leading benchtop Ultima multiphoton microscope technology,” added Kunal Ghosh, Ph.D., CEO at Inscopix. “The unique ability of this new system to acquire high-resolution brain data in three dimensions, and its seamless integration with our exclusive sample preparation-to-results workflows, make it an ideal tool for researchers studying neuronal circuits in freely-behaving animals.”
